Easter Operation 2021 will begin at 12.01am on Thursday, running through to 11:59pm on Monday, April 5, with motorists at risk of double demerits for speeding, seatbelt, mobile phone and motorcycle helmet offences.

Officers from Riverina Police District will be joined by both local and metropolitan Traffic and Highway Patrol Command units, focusing on high-risk driver behaviour.

"Six vehicles from Sydney will be deployed to some of our traffic hotspots where there have been recent fatalities and accidents," Riverina Highway Patrol Acting Sergeant Jamie Mooney said.

"It'll be all hands on deck, and with a lot of people travelling due to the relaxing of COVID-19 restrictions, we ask everyone to be patient on the roads, take a break, and remember it's better to arrive late than not at all."

Officers will also be targeting the Four Ds, being drink, drug, dangerous and distracted driving, and monitoring compliance with COVID-19 restrictions still in place across the state.

Riverina Police District Commander Superintendent Bob Noble said now is not the time to be complacent.

"We do not want to see an outbreak in regional NSW - or anywhere else for that matter - so it's important that the community remembers to practice good hygiene, maintain physical distancing and stay home if any symptoms arise," he said.

"It's critical that people are using the QR codes to sign in to venues, so in the event of an outbreak our contact tracers are able to reach people quickly and without any hassles.

"We understand people want to get out and about this weekend, but we implore everyone to do so in the safest way possible, be that on our roads or in our licensed premises and hospitality venues."